In most cases, digestive disorders are unrelated to lupus. The digestive tract is rarely affected during this disease. Digestive disorders are most often related to medications, such as taking anti-inflammatories, synthetic antimalarials or immunosuppressants. There may be heartburn, nausea, abdominal pain, poor digestion, or even diarrhea. Some symptoms are temporary, especially those related to taking synthetic antimalarials, that disappear spontaneously after a few weeks of treatment. In other cases, heartburn may warrant a gastroduodenal fibroscopy, to ensure the absence of inflammation or an ulcer of the mucosa. Stress, anxiety, tobacco and alcohol are also common causes of digestive disorders. More exceptionally, vascular involvement by inflammation or thrombosis of the digestive vessels may occur. Patients then describe "cramps" in the abdomen during digestion. It can also be functional colopathy ("irritable bowel"), as can be observed in the general population.