YES, the lymph nodes may increase in size (adenomegaly or lymphadenopathy) when lupus is active. These are inflammatory lymph nodes that do not warrant special treatment. They testify to the activation of the immune system that accompanies the flare of the disease and they regress with its control. Some may nevertheless persist over time.

However, lymphadenopathy can be seen in other diseases, infectious or tumoral, justifying a specific analysis. It is sometimes necessary to remove one of these nodes surgically, in order to analyse it under a microscope, in particular to look for microbes.