Hey there, how can we help?
The site dedicated to answering the most important questions around Lupus, verified by world renowned doctors.

Main indications in lupus

Lupus with joint involvement or visceral involvement (kidney, pleura, pericardium ...).


0.3 to 1 mg / kg / day in initial intensive treatment with the objective of gradually reducing the doses to the minimum effective dosage: generally of the order of 0.1 to 0.15 mg / kg depending on the clinical situation

Tablets of 20 mg, 10 mg, 5 mg and 1 mg; intramuscular solution 2.5 mg, syringes for subcutaneous injection

Orally (in 1 dose per 24 hours in the morning at breakfast), intravenous, intramuscular, subcutaneous

Key Drug Interactions

- Combination with nonsteroidal anti-inflammatory drugs may increase the risk of gastric ulcer

- The combination with diuretics may promote hypokalaemia (abnormal decrease in potassium levels)

- The combination with enzyme inducer drugs (rifampicin, barbiturates ...) must be done carefully

- In case of taking gastric acid inhibitors, wait at least 2 hours before taking Prednisone


Main side effects

- Water and salt retention (weight gain)

- Hypokalaemia (abnormal decrease in potassium levels)

- Osteoporosis

- Aseptic osteonecrosis

- Muscle weakness

- Epigastric pain (in the stomach area)

- Digestive ulcers

- Psychic disorders (euphoria, excitement, insomnia, confusion)

- Increased risk of infection (viral, parasitic, bacterial)

- Skin disorders: acne, skin atrophy, bruising (blue), hypertrichosis (excess hair on one area or over the whole body)

- Clouding of the lens (cataract), increased eye pressure (glaucoma)

- Rare immediate allergic reaction to sulphite excipients and parabens


- Infectious states (viruses, bacterial infections) or uncontrolled mycoses

- Progressive peptic ulcer

- Psychotic disorders

- Decompensated cirrhosis

- High blood pressure and/or condition

uncontrolled cardiac

Precautions for use

- Pregnancy: increased risk of diabetes and high blood pressure, especially for high doses >20 mg/day

- Breastfeeding: to be avoided when taking high doses >20 mg / day

- Diet: the diet must be rich in calcium, potassium, low in carbohydrates and fats, rich in proteins with the addition of calcium, vitamin D


- Blood glucose, kalemia, densitometry

- Clinical monitoring: assessment of tolerance, weight, blood pressure

Related Anexes

Share with your family