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Drugs for lupus contraindicated during pregnancy
  • NSAIDs: chronic use of all NSAIDs (including acetylsalicylic acid ≥ 500 mg/d and COX-2 inhibitors) is not recommended during pregnancy and is formally contraindicated from 24 weeks of amenorrhea.
  • Antivitamin K: contraindicated between 6 and 9 weeks of gestation,
  • Bisphosphonates: to be avoided in women of childbearing age given their storage in the bones and the uncertainties about their long-term effect in children.
  • Immunosuppressants: several are contraindicated given their teratogenic effects: mycophenolate mofetil or mycophenolic acid, cyclophosphamide, methotrexate
  • Thalidomide: can only be prescribed after negativity of a pregnancy test.
  • Belimumab and Anifrolumab are contra-indicated in pregnancy and lactation.
  • Ace inhibitors (ACE) and angiotensin II receptor antagonists (sartans): contraindicated in the 2nd and 3rd trimesters of pregnancy and not recommended in the 1st.
  • Voclosporin (lack of data)

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